Additionally, while research shows mixed results, there’s some evidence that taking a chemical from saffron called crocetin might decrease fatigue during exercise and help with increasing energy expenditure. (6) To get the antidepressant benefits of saffron, start with the the standard daily dose of 30 milligrams, used for up to eight weeks. If you have any existing condition that might interfere with saffron’s influence on serotonin metabolism (like depression, for example), it’s a good idea to get your doctor’s opinion first.

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